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Third Year Course Units
Dependencies: First year and second year chemistry core
courses
Syllabus:
Separational
Methods: Ion Exchange: Kinetics, Donan Equilibrium, Affinity; Solvent
Extraction: Distribution coefficient and distribution ratio, Extraction
strategies, Chelating agents for the extraction, Masking; Chromatography:
Elution chromatography, Selection of the mobile and stationary phases, Separation
mechanisms, Sorption Isotherms, Retention time, Distribution coefficient,
Capacity Factor, Selectivity, Efficiency, Resolution, Temperature (solvent
strength) programming, Band broadening process, van deemter Equation for GC, H
vs u curves for GC and LC, Chromatographic methods for qualitative and
quantitative analysis, Instrumentation, GC and HPLC trouble shooting,
Size-exclusion chromatography, Electrophoresis, Applications Electro analytical
methods; Coulometry, coulometric titration, electrogravimetry, polarography :
dc-, ac-, pulse, differential pulse, stripping voltametry, amperometry,
potentiometry, ion and molecular selective electrodes, carbon paste
electrodes potentiometric titration,
conductometry, conductometric titration.
Assessment: End of semester examination.
Suggested Readings: Text book of quantitative
inorganic analysis (A.I. Vogel), Determination of pH: theory and practice (R.G. Bates), Analytical chemistry (J.D.
Dick), Chemical separations and measurements: theory and practice (D.G. Peters,
J.M. Hayes and G.M. Hieftje)
Dependencies:
None
Syllabus:
Titrimetry/colorimetry/AAS
and AES and Electroanalytical Techniques.
Assessment: End of semester practical
examination.
Suggested Readings: Text book of quantitative
inorganic analysis (A.I. Vogel), Determination of pH: theory and practice (R.G.
Bates), Analytical chemistry (J.D. Dick), Chemical separations and
measurements: theory and practice (D.G. Peters, J.M. Hayes and G.M. Hieftje).
Dependencies:
None
Syllabus:
Soap
and detergents, Paints and varnishes, Pesticides, Silicates and some related
industries, Manufacture of Portland cement, setting and hardening, application
of homogenous and heterogeneous catalysis in industry.
Assessment:
End
of semester examination.
Dependencies:
None
Assessment:
End
of semester examination.
Dependencies:
None
Syllabus:
Electro-technology,
polymer-technology and Food-technology: Fermentation
Assessment:
End
of semester examination.
Dependencies: First year and second year chemistry core
courses
Syllabus: Quantum Mechanics & Computational methods. Exactly solvable problems; atomic units,
Approximate methods, Many electron systems, Born-Oppenheimer approximation,
Pauli exclusion principle, spin and spatial orbitals, Hartree products, Slater
determinants, configuration interaction, Hartree-Fock approximation, Coulomb
and exchange integrals, Hartree-Fock equations, Orbital energies, Koopamann
theorem, Brillouins theorem, Introduction of a basis, Roothaan equations,
orthogonalization of the basis, The self consistency procedure, Semi-empirical
and ab-initio calculations. Molecular Properties & Molecular Dynamics: The
electric dipole, vector addition of dipole moments, induced dipole moments,
Charge-charge interactions, charge-dipole interactions, dipole-dipole
interactions, dipole-induced dipole interactions, induced dipole-induced dipole
interactions, total attractive interactions, effect of rotation, Axilrod-Teller
formula, Mie potential, Lennard-Jones
potential, hydrogen bonding interactions, multipoles; Minimum energy structure of a molecule,
methods to obtain minimum energy; Molecular dynamics simulation, modeling
liquids and solvation.
Assessment:
End
of semester examination.
Dependencies: CH
2008, CH 3001 recommended.
Syllabus: Sampling and statistics, errors, accuracy;
sample standard deviation, precision, propagation of errors, confidence limits,
expression of the results of analysis, rejection criteria (Q-test);
Sequestration metal ions: Metal ligand complexes. Conditional formation;
Masking (Sequestration), a - coefficients and selection of masking
agents for titrimetry, precipitation, colour development, Medicinal and
industrial purposes; Metal ion speciation, sample ion increment method(SIIM);
Effect of sequestration on redox reactions, formal potential, Eh and pE , environmental redox parameters;
Kinetic Methods, Differential Methods, Integral Methods, Fixed time Methods and
Catalytic Methods.
Assessment: End of semester examination.
Suggested Readings: Quantitative analysis (R.A.
Day and A.L. Underwood), Chemical separation and measurements : Theory and
practice (D.G. Peters, J.M. Hayes and G,M. Hieftje), Chemical analysis: an
advanced text and reference (H.A. Laitinen and W.E. Harris), EDTA titrations (H.A.
Flaschka), Complexation in analytical chemistry (A. Ringbom), Complexometric
titrations (G. Schwarzenbach).
Dependencies:
None
Syllabus:
Industrial
standardization: Historical development, aims, objectives and benefits of
standardization; Standardization space – Levels, Types and Aspects; Total
Quality Management: Basic concepts and definition of quality; Quality control
assurance and quality systems; Quality policy, Goods and objectives; Leadership
for Quality and Human Resources Management: Motivation and communication for
quality, Teamwork and characteristics of effective teams; Management of
Quality: Quality systems, ISO 9000 standard, Quality manual, Quality auditing.
SLNQA scheme, Introduction to ISO 14000 standard on environmental management
systems: Economics of quality and poor quality customer Focus and customer
ease, Vendor (Supplier) Relations, Inspection planning ; Techniques for Quality
Improvement: Introduction to the 7 basic tools of quality control, Introduction
to new management tools, Problem-solving process.
Assessment: End of semester examination.
Suggested Readings: Will be announced during the
course.
Dependencies: CH 1003, CH 3027 required.
Syllabus: Nucleic acid separation and analytical
methods.
Assessment: End of semester practical
examination.
Suggested Readings: Molecular cell biology (H. Lodish et.al.), Genes VII (B. Lewin).
CH
3010 Environmental Chemistry (30L,2C)
Dependencies: CH 2006 recommended.
Syllabus: The chemistry of atmosphere, the oxygen and
nitrogen cycles, chemical interaction between the atmosphere and the
hydrosphere, anthropogenic input to the atmosphere. Tee hydrologic cycle, the
role of water in the environment, Evaporite; carbonate and silica formation in
the oceans, interaction particulate matter and sea water, anthropogenic inputs
to land-based hydrosphere and oceans. Industrial effluents; type of effluents,
chemical parameters, sampling and analysis. Effluent treatment processes;
Environmental soil chemistry, the structure of silicate minerals, chemical
weathering reactions and weathering processes, the chemistry of reservoirs,
lakes and rivers. Water quality, potable
water, water for agriculture industries; Solid wastes, domestic and municipal
wastes, land fill policy, toxic and hazardous wastes. Non hazardous industrial
wastes, environmental soil chemistry, solid waste treatment; Health related
toxic chemicals, metals and non metals, inorganic compounds, organic compounds;
Environmental analytical chemistry, sampling air, water and solid matter.
Analysis of pollutants in air, analysis of water, analysis of organic and mineral
based solids.
Assessment: End of semester examination.
Suggested Readings: ASTM and Sri Lanka
Standards, Methods for chemical
analysis of fresh water (H.L. Golterman), The hydrogeochemical Atlas of Sri
Lanka (C.B. Dissanayake, S.V.R. Weerasooriya), Environmental Chemistry (R.D.
Raiswell, R.D. P. Brimblecombe and P.S. Liss).
CH
3021 Spectroscopy (45L, 3C)
Dependencies:
First year and second year chemistry core courses.
Syllabus:
NMR
Spectroscopy: Pulsed FT NMR and high resolution NMR- spectroscopy, 13C
NMR spectroscopy, Coupling constants and mechanism of coupling, Chemical
equivalence and magnetic equivalence, second order spectra, Homotropic,
enanatitropic and diastereotopic systems, shift reagents and chiral resolving
agents, protons on heteroatoms, The DEPT experiment and the APT experiment.
Introduction to 2D NMR COSY, HETCOR, HMQC, HQBC spectra, Use of NMR in elucidation biosynthesis
pathways. Applications in structure elucidation 31P, 19F, 1H and quadrupolar nuclei; Mass
Spectrometry, Atomic absorption, emission and inductively coupled plasma
spectroscopy, fluorescence; spectral, physical and chemical sensitivities and
detection limits. Electron Spin Resonance Spectroscopy (ESR), Nuclear Quadruple
Resonance Spectroscopy (NQR) and Mössbauer
spectroscopy; Vibration and Rotation Spectroscopy Microwave spectroscopy of
linear polyatomic molecules; Introduction to microwave spectra of symmetric
top, spherical top, asymmetric top and molecules. Vibrational-rotational
spectroscopy of linear triatomic / diatomic molecules, effect of nuclear spin,
Raman Spectroscopy.
Assessment: End of semester
examination.
Suggested
readings: Physical
methods for chemists (R.S. Drago), Spectroscopy (D.R. Browning), Structural
methods in inorganic chemistry (E.A.V. Ebsworth, D.W.H. Rankin and S. Cradock),
Modern NMR spectroscopy (J.K.M. Sanders and B.K Hunter), Introduction to
spectroscopy - A guide to students of organic chemistry (D.L. Pavia, G.M.
Lampman and G.S. Kriz).
Dependencies:
First year and second year chemistry core courses.
Syllabus:
Biosynthetic
Pathways, Elucidation of biosynthetic pathways, Biosynthesis of fatty acids
and derivatives, poly ketides,
terpenoids and steroids, shikimates, Alkaloids and compounds of mixed biogenesis; Carbohydrate and Lipids:
Occurrence, nomenclature, configurational relationships, conformational
analysis, anomeric and reverse anomeric effects, reactions of anomeric and
non-anomeric carbon atoms, reactions of the hydroxyl groups, reducing and
non-reducing sugars, nature of di-, tri-, polysacaccharides, starch, glycogen,
cellulose, chitin, glycoproteins and glycolipids; Terpenoids, Steroids and
alkaloids. Selected examples and biological activity.
Assessment: End of semester
examination.
Suggested readings: Will be announced during the course.
Dependencies:
First year and second year chemistry core course unites.
Syllabus:
Advanced
Coordination Chemistry: Crystal Field Theory and Chelate compounds, Octahedral
Site Stabilization Energy, Electronic spectra of transition metal complexes :
Russell-Saunders Coupling, Orgel
diagrams, Tanabe-Sugano diagrams. Magnetic properties: classification of the
types of magnetic behavior: Crystal Field interpretation of the origin of
paramagnetism. Organometallic Chemistry and Catalysis: Introduction to
Organometallic Chemistry, Metal-ligand bonding, Introduction to important p-bonding ligands, Dewar-Chatt-Duncanson model, metal-ligand reactivity patterns,
reactivity of metal-bound ligands, Homogeneous catalysis, Chemistry of
ferrocene, Synthesis, structure and
bonding; Inorganic Reaction Mechanisms: ligand substitution reactions,
classification of substitution reaction mechanism, Substitution reactions of
octahedral and square planar metal complexes, strerochemical changes,
isomerization, fluxional behaviour, electron transfer reactions. Bio-inorganic
Chemistry: Principles of
coordination chemistry related to bioinorganic chemistry, Metalloproteins,
Metalloenzymes, Other metal binding biomolecules – structure and function.
Assessment: End of semester examination.
Suggested Readings: Inorganic and organometallic
reaction mechanisms (J.D. Atwood), Inorganic reaction mechanisms (M.L. Tobe),
Mechanisms of inorganic reactions (I. Basalo and R.G. Pearson), Cluster
molecules of p-block elements (C.E. Housecroft), Multiple bonds between metal
atoms (F.A. Cotton and R.A. Walton), Physical methods for chemists (R.S.
Drago), Spectroscopy (D.R. Browning), The Organometallic Chemistry of the
Transition metals (Robert H. Crabtree), Concise Inorganic Chemistry ( J.D.
Lee), Inorganic Chemistry (J.E. Huheey), Advanced Inorganic Chemistry (F.A.
Cotton and R. Wilkinson), Principles of Bio Inorganic Chemistry (S.J. Lippard
and J.M. Berg), Bio-coordination Chemistry (D.E. Fenton), Biochemistry (L.
Stryer).
Dependencies:
None
Syllabus:
Chemistry
of therapeutic agents; Antiseptics and
Disinfectants; Chemotherapy and chemotherapeutic agents: Sulphonamides:
Antimalarials, Antibiotics, Antiamoebics, Anthalmitics, Antifungal,
Antiturbercular and Antileprotic drugs; Antivirals including drugs acting on
HIV, Antineoplastics, Newer Antibactirial agents, Hypoglycemics, Diuretics,
Local anesthetics, Purgative and Cathartics, Antieleptics, Gastrointestinal
drugs, solutions correcting water, electrolyte and acid-base disturbance.
Inorganic Pharmaceuticals.
Assessment: End of semester
examination.
Suggested
readings: Bently
and Driver’s textbook of pharmaceutical chemistry (L.M. Atherden), Modern
inorganic pharmaceutical chemistry (C.A. Disher, T. Medwic and L.C. Baily),
Physical Pharmacy (A. Martin, P. Bustamante and A.H.C. Chen), Hand book of
Pharmaceutical excipients (A. Wade and P.J. Walker).
CH
3026 – Industrial Chemistry and Chemical Technology (45L, 3C)
Dependencies:
None
Syllabus:
Soap
and detergents, Paints and varnishes, Pesticides, silicates and some related
industries, Portland cement manufacture, setting and hardening. Application of
homogenous and heterogeneous catalysis in industry; Electro-technology,
polymer-technology and Food-technology: Fermentation. Physical and extraction
metallurgy.
Assessment: End of semester
examination.
Suggested readings: Will be announced during the course.
Syllabus: The structure and organization of cellular
genomes; prokaryotic and eukaryotic genomes. Introduction to macromolecular
synthesis; DNA replication , DNA repair and mutagenesis, DNA rearrangements;
gene conversion and crossover. RNA synthesis and processing; transcription in
prokaryotes, regulation of transcription.
Assessment: End of semester
examination.
Suggested
readings: Molecular
genetics of bacteria (L. Synder, W.
Champness), Genes VII (B. Lewin).
CH 3029 – Organic Chemistry (45L, 3C)
Dependencies:
First year and second year chemistry core courses.
Syllabus:
Kinetics
and Mechanisms in Organic Chemistry, Intramolecular rearrangements; Free
radicals: Characteristics of organic radical, Detection of free radicals,
Radical production, Radical termination, Chain reactions, Radical
substitutions, Rearrangements of radicals; Carbenes and Nitrenes: Formation,
structure and reactions. Nitrenes: Formation and reactions of nitrenes;
Carbanions : Stability, Formation, rearrangements and reactions; The Hammett equation
: Applications, free energy diagrams; Failures and modifications Hammett
equation; Yukawa – Tsuno equation and
its applications. Taft equation. Steric effects in organic reactions. Solvent
effects; Confirmation effects; Curtin Hammett principle; Cramm’s rule. Isotope
effects, Steroelectronic effects; Winstein and Brown explanations; Principles
in Organic Synthesis: reterosynthesis, disconnection, synthon, Key reaction,
synthetic equivalent. Protecting groups in synthesis. Linear vs. Convergent
synthesis, Natural products total synthesis; Heterocyclic Chemistry, Orbital
picture, aromaticity, physical properties, uses, preparation and reactions of
pyrrole, furan, thiophene, pyridine, indole, quinoline and isoquinoline.
Assessment: End of semester
examination.
Suggested readings: Will be announced during the course.
Dependencies:
CH 1003, 2003
Syllabus:
Advanced
aspects in Analytical, Inorganic, Organic and Physical Chemistry, synthesis and
characterization.
Assessment: End of semester
practical examination.
Suggested readings: Will be announced during the course.
CH 3031 Symmetry in Chemistry(15L, 1C)
Dependencies:
First year and second year chemistry core courses.
Syllabus:
Introduction
to symmetry: Symmetry elements and point groups Elementary group theory; Matrix
representation of symmetry operations, Reducible and irreducible
representations, Analysis of IR and Raman spectra. Selection rules for IR and
Raman. Fermi resonance. Projection operators. Symmetrically
equivalent coordinates. Molecular orbital diagrams: Symmetry-adapted MO's using
projection operators; Linear combination of atomic orbitals. Hückel molecular
orbital calculations. s and p bond formation (hybridization)
Assessment: End of semester
examination.
Suggested readings: Quantum chemistry (D.A. McQuarrie), Quantum chemistry (I Levine), Molecular modeling: Principles and applications (A.R. Leach), Physical Chemistry (P.W. Atkins).
CH
3032 Computer programming in Chemistry (30L,30P, 3C)
Dependencies: First year and second year chemistry core
courses.
Syllabus: Programming with FORTRAN or C++, equation
solving methods, numerical differentiation, numerical integration (Trapezoidal
method, Simpson rule, Runga-kutta method).
Matrix algebra; inversion, eigen values of a tri-diagonal matrix, reduction
to tri-diagonal form, use of diagonalization routines. Curve fitting; linear
and non-linear least square methods. Molecular simulation; Monte Carlo and
molecular dynamics methods. Programming and software handling on Linux
operating system, Statistical analysis of experimental data, molecular docking
and conformational searching.
Assessment: End of semester
examination.
Suggested readings: Quantum chemistry (D.A. McQuarrie), Quantum chemistry (I Levine), Molecular modeling: Principles and applications (A.R. Leach), Physical Chemistry (P.W. Atkins) Computer Simulation of Liquids (M.P. Allen & D.J. Tildesley).
CH 3050 – Protein
Structure and Chemistry of Metabolic Pathways (30L, 2C)
Dependencies: None
Syllabus: Advanced aspects of protein structure: Active site residues of different
enzymes and positioning; Bioenergetics: Application of energy relationships and
electrochemistry to biological systems; Function of coenzymes, Role of high
energy compounds: Chemical basis for large free energy of “hydrolysis” of ATP,
PEP,1,3-bisphosphoglycerate, Acetyl Coenzyme A; Enzyme catalysis: Acid-base
catalysis, covalent catalysis, Metal ion catalysis, Electrostatic catalysis,
proximity and orientation effects, preferential binding of the transition state
complex; Metabolic pathways, regulation of pathways. Metabolic disorders and
inborn errors of metabolism
Assessment: End of semester
examination.
Suggested readings: Biochemistry (A.L. Lehninger),
Biochemistry (C.K. Mathews, K.F. vanHolde), Enzyme kinetics and catalysis (S.A. Deraniyagala).
CH 3051 – Advanced
Molecular Biology (45L, 3C)
Dependencies: None
Syllabus: The structure and organization of cellular
genomes: prokaryotic and eukaryotic genomes (Supercoiled nature of DNA,
telomere structure, extrons and introns). Introduction to macromolecular
synthesis: DNA replication (initiation of replication,replication fork, okazaki
fragment, accessory proteins, termination of replication) DNA repair (light
dependent and independent pathways;excision repair, SOS resposes, homologous
recombination-PR enzyme,Uvr system, Mut system and Rec system) and mutagenesis,
DNA rearrangments; gene conversion and crossover; RNA synthesis and processing:
transcription in prokaryotes, regulation of transcription (RNA polymerase, transcription
initiation, promoter region, elongation, transcription termination (Rho
dependent pathway); Bioenergetics and metabolism: Mitochondria, Chloroplast, Peroxisome.
Assessment: End of semester
examination.
Suggested readings: Gene VII (B. Lewin), The cell (G.M.
Cooper), Molecular biology of the cell (J. Wilson, T. Hunt).
CH
3052 – Biophysical Chemistry (45L, 3C)
Dependencies: None
Syllabus: Enzyme Kinetics: Unisubstrate enzyme
kinetics, reversible and irreversible enzyme inhibition, nomenclature and
formulations of multisubstrate enzyme systems, rate equations and kinetics of
bi substrate systems, dead end inhibition and product inhibition, rapid
equilibrium random product inhibition. Distinguishing between mechanisms using
kinetic models, rapid reaction kinetics, allosteric enzymes- models to account
for cooperative phenomena; Physical Properties of Macromolecules: Measures of
homogeneity, osmotic pressure, (osmotic pressure equations, Van’t hoff’s law
and its application, Donnan effect. Light scattering: Raleigh equation,
relationship between light scattering
and osmotic pressure), diffusion, sedimentation in an ultracentrifuge
(Johnston-Ogston effect), equilibrium centrifugation, ultra centrifugation,
density centrifugation; X-ray Crystallographic studies on proteins; Isolation
and Separation of Proteins: Precipitation
of proteins, isoelectric precipitation, salting in , salting out, salt
fractionation, ion exchange chromatography, affinity chromatography, gel
chromatography, isoelectric focusing, zone electrophoresis, gel
electrophoresis, gradient electrophoresis, counter current distribution.
Assessment: End of semester
examination.
Suggested readings: Biochemistry (A.L. Lehninger),
Biochemistry (C.K. Mathews, K.F. vanHolde), Enzyme kinetics and catalysis (S.A.
Deraniyagala).
CH
3053 – Nucleic Acid Technology (45L, 3C)
Syllabus:
Recombinant
DNA technology: Creation of recombinant molecules: restriction and DNA
modifying enzymes, prokaryotic vector/ host systems (plasmids, phage and cosmid
vectors), cloning in yeast; Strategies for cloning and construction of genomic
and cDNA libraries. Analysis of cloned genes: Agarose gel electrophoresis,
southern and northern hybridization, polymerase chain reaction . DNA seqencing
methods, pulse-field gel electrophoresis, RFLP mapping, DNA fingerprinting,
Chromosome walking. Techniques in gene isolation : hybridization with nucleic
acids and oligonucleotide probes, identification using antibody probes,
differential hybridization. Chemical synthesis of DNA. Antisense RNA
technology: Synthesis and properties of oligonucleoside methylphosphonates, oligo(nucleoside
phosphorothiotes). Modified oligodeoxynucleotides as antisense therapeutics,
applied antisense oligonucleotide therapeutics; Recombinant DNA in medicine and
industry: Protein engineering and invitro mutagenesis, recombinant proteins, recombinant drugs.
Assessment: End of semester examination.
Suggested readings: Recombinant
DNA (J.D. Watson, M. Gilman, J.
Witkowski and M. Zoller), Genetic engineering: principles and methods (J.K.
Setlow).
CH
3054 – Nutritional and Clinical Biochemistry (30L, 2C)
Syllabus: Energy and protein requirements. Fat soluble
vitamins(Vitamin A, D, E and K) and Water soluble vitamins (mainly folate and vitamin B12)- sources,
metabolism, biochemical function, assessment, causes and consequences of
deficiency and excess. Trace elements: Iron- deficiency and consequences,
bioavailability, nonheam iron and heam iron, enhancement of absorption, stages
in development of deficiencies, prevention of deficiencies. Iodine- metabolism,
function of thyroid hormones, assessment of thyroid function. Zinc, Selenium
and fluoride. Diet and chronic disorders- obesity, diabetes mellitus type 2,
cardiovascular diseases, role of lipoproteins in atherogenesis and thrombosis, role of diet; Introduction to
Clinical Biochemistry. Liver disorders,
renal disorders, IHD. Clinical tests versus cost. Understanding the purpose of
each clinical test, accuracy, quality control, automation. Basis of common
laboratory tests- blood glucose,
albumin, urea and lipid profile. Special investigations.
Assessment: End of semester
examination.
Suggested readings: Will be announced during the course.
CH
3055 – Practical Biochemistry and Molecular Biology (240P, 8C)
Syllabus:
Biochemical
methods, principles used in the study of nucleic acids, protein, carbohydrates
and lipids.
Assessment: End of semester
practical examination.
Suggested
readings:
Molecular cloning : A laboratory manual (J. Sambrook, E.F. Fitsch and T.
Maniatis), An introduction to recombinant DNA techniques (B.P. Cttackett, J.K.
Fuchs and J.W. Messing).
Syllabus:
Antiseptics
and Disinfectants, Anti-infective agents : The concept of chemotherapy, the
structure, function and mode of action of the antibiotics, sulphanamides,
antitubercular, antimalarial, antifungal and other protozoal agents;
Antimalarials: Life cycle of parasite, drugs acting on different stages.
Antibiotics; Antiamoebics: General aspects of infection, life cycle of
parasite. Anthalmintics; Antifungal;
Antitubercular and antileprotic Drugs. Antivirals including drugs acting on
HIV: Antineoplastics; Newer Antibacterial
agents; Hypoglycemics; Diuretics; Local anesthetics ;
Sedatives,
hypnotics and CNS drugs; Antiepileptics; Gastrointestinal drugs; Solutions
correcting water, electrolyte and acid-base disturbances : Oral rehydration salts, Glucose, Glucose with
Sodium Chloride, Potassium Chloride, Sodium Chloride, Sodium hydrogen
carbonate. Inorganic pharmaceuticals : Aluminium, Magnesium, Sodium, Potassium,
Iron, Iodine, Calcium, Mercury, Silver, Gold, Lithium, Cobalt, Chlorine,
Fluorine, Titanium, Chemistry of pharmaceutical excipients.
Assessment: End of semester
examination.
Suggested
readings: Bently
and Driver’s textbook of pharmaceutical chemistry (L.M. Atherden), Modern
inorganic pharmaceutical chemistry (C.A. Disher, T. Medwic and L.C. Baily), Physical
Pharmacy (A. Martin, P. Bustamante and A.H.C. Chen), Hand book of
Pharmaceutical excipients (A. Wade and
P.J. Walker).
CH
3071 – Pharmaceutics I (45L, 3C)
Syllabus: Introduction to
dosage forms: Good manufacturing practice: Design of dosage forms;
Pharmaceutical solvents : Quality of water : Detailed study from the view point
of water as universal pharmaceutical vehicle,
Non aqueous solvents. Solutions: Solubility, problems associated with
prediction of solubility, methods of increasing solubility; cosolvents,
complexation, salts, surfactants. Interfacial phenomena; Interfaces and
surfaces; surface and interfacial tension and their measurement, surface free
energy, contact angles and their uses; Adsorption equation, factors affecting
adsorption isotherms; Pharmaceutical applications of adsorption phenomena;
surface films, film balance studies and their uses in pharmacy; Rheology:
solids, liquids, semi-solids, colloids, molecular weight. Equipment for
viscosity measurement, non-Newtonian systems, viscoelastic properties;
Pharmaceutical Technology: Bulk Characteristics, Micrometrics, Non-sterile
monophasic systems, Dispersed systems, Emulsions, Solid dosage forms,
Tablets, Coated tablets, Capsules, Soft gelatin capsules, Semisolid dosage
forms: Creams, Gels and Jellies.
Assessment: End of semester
examination.
Suggested
readings:
Bently’s Text book of pharmaceutics (E.A. Rawlins), Pharmaceutical practice
(D.M. Collett and M. Aulton), Ramington’s Pharmaceutical science (A. R.
Gennaro), Pharmaceutics: The science of dosage from design (M. Aulton), Good
manufacturing practice and inspection by World health organization,
Pharmaceutical engineering (K. Sambamurthy).
CH 3072 –
Pharmaceutical Microbiology (45L, 3C)
Syllabus:
The
nature of microorganisms and their role in causing diseases and spoilage of
pharmaceuticals; Hazards associated with microbial contamination of
pharmaceuticals; The chemical agents used to control microorganisms in
pharmaceuticals: The physical agents used to control microorganisms in
pharmaceuticals; Microbiological control methods used in manufacture of
pharmaceuticals; Resistance of
microorganisms to chemical and physical antimicrobial agents; Pharmaceutical application
of microbiological techniques: Measurement of antimicrobial activity, Counting
& identification of micro-organisms in a pharmaceutical product, Sterility
and pyrogen testing to test the preservative efficacy, Challenge tests: to test
the preservative efficacy;
Microbiological quality assurance: Limits and Standards: official &
unofficial, Methods used to control microbial contamination of products:
Control of raw materials, Formulation aspects, Good manufacturing practice
(GMP), Evaluation of a microbial quality of a pharmaceutical product;
Endotoxins, exotoxins, vaccines, sera and other immunological products;
Microbiologically generated pharmaceuticals: vitamins, enzymes, antibiotics,
alcohol, insulin, microbiology of water, microbiology of air, major microbials
(bacterial, protozoal fungal, viral), diseases of human and animals as
applicable to pharmacy .
Assessment: End of semester
examination.
Suggested readings: Disinfection and sterilization (G.
Sykes), Medical microbiology
(Cruicshank).
Syllabus:
Cell
and Tissues: Typical human cell, structure and basic functions of each
component; Basic Embryology and Genetics, Tissue: Structure and basic functions of Epithelial tissue/glands,
Connective tissue including bone and cartilage, Muscle tissue, Nerve tissue ; Matrix substances: Extra
cellular fluid, Lymph, Plasma, Cerebrospinal fluid; Blood: Composition and
functions; Cardiovascular System: The Heart: structure, function, common
congenital abnormalities; Blood vessels:
Structure, classification and function; Pulmonary circulation; Systemic circulation; Respiratory System;
Gastrointestinal System; Alimentary tract: Mouth, Pharynx, Oesophagus, Stomach, Small & large intestine; Biliary tract: Pancreas: Lymph and Reticulo-Endothelial
System; lymph, lymph nodes, tonsils, spleen, thymus and lymphoid aggregates,
Reticuloendothelial cells; Locomotor System: Bones, Joints, Muscles; Nervous System: Central nervous
system, Peripheral nervous system, Autonomic nervous system; Special Senses:
Eye, Ear, Other senses and their organs: taste and smell, General senses :
touch/pressure/pain/temperature & their receptors; Urinary System: Kidneys
and urethra, Bladder and urethra; Reproductive System: Male genital system,
Female genital system and breast, Placenta; Endocrine System: Pituitary gland,
Thyroid gland, Parathyroid gland, Adrenal glands, Pancreas, Testis/Ovary,
Placenta, Thymus, Pineal body, Stomach, Intestinal lining; Integumentary
System; Physiology; Homeostasis and body fluids
Assessment: End of semester
examination.
Suggested
readings:
Basic human physiology (Guyton), Medical physiology (Ganong), Anatomy and
physiology in health and Illness (Ross and Wilson), Gray’s Anatomy.
CH
3074 – Pharmacology I (45L, 3C)
Dependencies: None
Syllabus:
Terms
and definitions, nomenclature of drugs,
dosage forms, routes of drug administration, pharmacokinetics, plasma
elimination half life, clearance, steady state, first pass metabolism, zero and
first order kinetics, therapeutic window, pharmacodynamics, receptors, channel
and molecular aspects of drug action, agonists (stimulants) and antagonists
(blockers), competition, drug development, clinical trials, placebo, efficacy,
safety, post-marketing surveillance. Concepts of health and disease, definition
and detection of disease, diagnosis, treatment and prevention of disease,
therapeutic options, pharmacotherapy. Microbial pathology and chemotherapy,
principles of antimicrobial chemotherapy, classes of antimicrobials,
antibiotics, antimicrobial chemoprophylaxis, antimicrobials in combination,
antiviral and antifungal drugs, antiprotozoals including antimalarials,
anthelmintics. Principles of neuromuscular and neurohumoral transmission,
synthesis and inactivation of acetylcholine and noradrenaline, nicotinic and
muscarinic receptors, their stimulants and blockers, anticholoneesterases,
anticholinergic drugs, organophosphate insecticide poisoning and its
management, adrenergic receptors, selectivity and adrenoceptor stimulants and
blockers, ganglion blockers.
Assessment: End of semester
examination.
Suggested readings: Pharmacology (H.P. Rang, M.M. Dale
and J.M. Ritter), Clinical pharmacology (L. Bennet), Basic and clinical
pharmacology (B.G. Katzung).
CH 3075 – Practical
Pharmacy (240P, 8C)
Dependencies: None
Syllabus:
Biochemistry,
Pharmaceutics, Pharmaceutical chemistry, Pharmaceutical Analysis & Nuclear
Pharmacy, Pharmaceutical Microbiology.
Assessment: End of semester
practical examination.
Suggested
readings: Practical
pharmaceutical chemistry part 1 and part 2 (Backett and Stenlake), Jenkins’
Quantitative pharmaceutical chemistry (Knevil and Digangi), Pharmaceutical
chemistry volume 2 (drug analysis) (Roth, Eager and Troschutz), The British
Pharmacopoeia , The United States Pharmacopoeia.
CH
3090 – Practical Computational Chemistry
(240P, 8C)
Dependencies: CH 3006 required.
Syllabus: Projects involving
calculations of properties of molecular systems, clusters and solvated
molecules. Modeling molecular systems in various environments. Solving chemical
problems using various software such as Gaussian, Mopac, HyperChem etc.
Assessment: End of semester
practical examination.
Suggested readings: Molecular modeling: principles and applications (A.R. Leach). Computer Simulation of Liquids (M.P. Allen & D.J. Tildesley).
Department of Chemistry, Faculty of Science, University of Colombo,
P.O. Box 1490, Colombo 03, Sri Lanka.
Tel : (9411) 2583105-7, Ext.225 Fax : (9411) 2503148, (9411) 2587239
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Last Updated October 2011